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Review
. 2014 Mar;41(1):119-31.
doi: 10.1016/j.clp.2013.09.004. Epub 2013 Dec 12.

Pharmacologic neuroprotective strategies in neonatal brain injury

Sandra E Juul  1 , Donna M Ferriero  2
Affiliations
Review

Pharmacologic neuroprotective strategies in neonatal brain injury

Sandra E Juul et al. Clin Perinatol. 2014 Mar.

Abstract

This article explains the mechanisms underlying choices of pharmacotherapy for hypoxic-ischemic insults of both preterm and term babies. Some preclinical data are strong enough that clinical trials are now underway. Challenges remain in deciding the best combination therapies for each age and insult.

Keywords: Brain injury; Hypoxic-ischemic encephalopathy; Preconditioning; Prematurity.

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Figures

Figure 1
Figure 1
The injury cascade as it occurs over time. Potential therapeutics are inserted over the course of the cascade. See text for details on these agents.
See this image and copyright information in PMC

References

    1. Hamilton BE, Hoyert DL, Martin JA, Strobino DM, Guyer B. Annual summary of vital statistics: 2010-2011. Pediatrics. 2013;131:548–58. - PMC - PubMed
    1. O’Shea TM, Allred EN, Dammann O, et al. The ELGAN study of the brain and related disorders in extremely low gestational age newborns. Early human development. 2009;85:719–25. - PMC - PubMed
    1. Stoll BJ, Hansen NI, Bell EF, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010;126:443–56. - PMC - PubMed
    1. Gargus RA, Vohr BR, Tyson JE, et al. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics. 2009;124:112–21. - PMC - PubMed
    1. Lodygensky GA, Vasung L, Sizonenko SV, Huppi PS. Neuroimaging of cortical development and brain connectivity in human newborns and animal models. J Anat. 2010;217:418–28. - PMC - PubMed

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