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Comment
. 2014 Feb 10;28(3):221-2.
doi: 10.1016/j.devcel.2014.01.025.

CAMSAPs add to the growing microtubule minus-end story

Victoria C Silva  1 , Lynne Cassimeris  2
Affiliations
Comment

CAMSAPs add to the growing microtubule minus-end story

Victoria C Silva et al. Dev Cell. .

Abstract

Free microtubule minus ends, found in many differentiated cells, contribute to polarized motility. Work from Jiang et al. (2014) in this issue of Developmental Cell shows how mammalian CAMSAP proteins stabilize minus ends, providing a key piece to the puzzle of how these minus ends are formed and stabilized.

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Figures

Figure 1
Figure 1. CAMSAPs stabilize MT minus ends
(A) Schematic diagram of CAMSAP2 addition to MT minus ends coincident, or slightly after, tubulin addition. CAMSAP2 binds relatively strongly to the MT lattice and its length along MTs is controlled by katanin. CAMSAP2 bound to MTs also acts as a stabilizer on the opposite end, allowing depolymerizing plus ends to resume growth. (B) CAMSAP2 and/or 3 levels dictates the type of MT array formed. Higher concentrations of CAMSAPs favors free, unanchored MTs while lower concentrations favor centrosome-anchored MTs. (C) Examples of free and centrosomal-anchored MT organizations in differentiated, polarized cell types.
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