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Comment
. 2014 Mar;24(3):261-2.
doi: 10.1038/cr.2014.22. Epub 2014 Feb 14.

Histone glutamine methylation afFACTing rDNA transcription

Heinrich Leonhardt  1 , Sandra B Hake  2
Affiliations
Comment

Histone glutamine methylation afFACTing rDNA transcription

Heinrich Leonhardt et al. Cell Res. 2014 Mar.

Abstract

Chemical modifications of histone proteins directly and indirectly affect chromatin structure and thereby contribute to the multilayered control of diverse DNA-based processes. A recent study in Nature enriches this list of enzyme-dependent posttranslational histone marks by H2A glutamine methylation that appears to be dedicated to only one specific cellular process, the regulation of nucleolar rDNA transcription.

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Figures

Figure 1
Figure 1
H2A glutamine (Q) methylation by human (h)Fibrillarin or yeast (y)NOP1 methyltransferase at the rDNA locus impedes FACT binding, providing a novel epigenetic link between RNA polymerase I (RNAPI) transcription and ribosome biogenesis.
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Comment on

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