Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014;13(5):693-4.
doi: 10.4161/cc.28088. Epub 2014 Feb 4.

Cell-size control: complicated

Yi-Hua Zhu  1 , Jian-Qiu Wu  2
Affiliations
Comment

Cell-size control: complicated

Yi-Hua Zhu et al. Cell Cycle. 2014.
No abstract available

Keywords: Cdr2 kinase; Pom1 kinase; cell division; cell size; fission yeast; mitotic entry.

PubMed Disclaimer

Figures

None
Figure 1. Current understanding of regulations on mitotic entry. Cdr1 and Cdr2 kinases are inhibited by Cdr1 inhibitor Nif1, cell polarity component Skb1, and Pom1 kinase, whereas the NIMA kinase Fin1 positively regulates the whole pathway (dashed box) through an unknown mechanism. Activated Cdr1/Cdr2 phosphor-inhibit Wee1 kinase, which in turn relieves Cdk1 inactivation. The Polo kinase Plo1 accumulates on the SPB to promote mitotic entry. Its localization also responds to stress signals from MAPK and TOR, as well as Fin1. Clp1 phosphatase controls the mitotic timing by dephosphorylating Cdc25 phosphatase. All the inputs control the balance between Cdc25 and Wee1 to ensure a proper cell size and timing of cell division.
See this image and copyright information in PMC

Comment on

References

    1. Moseley JB, et al. Nature. 2009;459:857–60. doi: 10.1038/nature08074. - DOI - PubMed
    1. Martin SG, et al. Nature. 2009;459:852–6. doi: 10.1038/nature08054. - DOI - PubMed
    1. Bhatia P, et al. Cell Cycle. 2014;13 doi: 10.4161/cc.27411. In press. - DOI - PubMed
    1. Almonacid M, et al. Curr Biol. 2009;19:961–6. doi: 10.1016/j.cub.2009.04.024. - DOI - PubMed
    1. Petersen J. Biochem Soc Trans. 2009;37:273–7. doi: 10.1042/BST0370273. - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources