Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014;13(5):685-6.
doi: 10.4161/cc.27857. Epub 2014 Jan 21.

DrICE resurrects Grim to antagonize DIAP1

Ting-Chun Yeh  1 , Shawn B Bratton  2
Affiliations
Editorial

DrICE resurrects Grim to antagonize DIAP1

Ting-Chun Yeh et al. Cell Cycle. 2014.
No abstract available

Keywords: DIAP1; DrICE; Grim; UbcD1; ubiquitin.

PubMed Disclaimer

Figures

None
Figure 1. Regulation of Grim by DIAP1 and caspases. Grim interacts with DIAP1 through its BIR1 and BIR2 domains. BIR2-bound Grim is ubiquitinylated on Lys136, so that when Grim levels are relatively low, most Grim is ubiquitinylated and degraded by the proteasome (prosurvival). However, at higher Grim levels, DrICE is activated and cleaves Grim at Asp132, liberating its C terminus including any ubiquitin chains linked to Lys136 (prodeath).
See this image and copyright information in PMC

Comment on

References

    1. Bratton SB, et al. J Cell Sci. 2010;123:3209–14. doi: 10.1242/jcs.073643. - DOI - PMC - PubMed
    1. Lüthi AU, et al. Cell Death Differ. 2007;14:641–50. doi: 10.1038/sj.cdd.4402103. - DOI - PubMed
    1. Ditzel M, et al. Nat Cell Biol. 2003;5:467–73. doi: 10.1038/ncb984. - DOI - PubMed
    1. Yeh TC, et al. Proc Natl Acad Sci U S A. 2013;110:14284–9. doi: 10.1073/pnas.1306179110. - DOI - PMC - PubMed
    1. Tapadia MG, et al. J Biosci. 2011;36:531–44. doi: 10.1007/s12038-011-9092-3. - DOI - PubMed

MeSH terms

LinkOut - more resources