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Editorial
. 2014;13(5):679-80.
doi: 10.4161/cc.27853. Epub 2014 Jan 21.

Skp2: a dream target in the coming age of cancer therapy

Chia-Hsin Chan  1 , John Kenneth Morrow  2 , Shuxing Zhang  2 , Hui-Kuan Lin  3
Affiliations
Editorial

Skp2: a dream target in the coming age of cancer therapy

Chia-Hsin Chan et al. Cell Cycle. 2014.
No abstract available

Keywords: Skp2 inhibitor; cancer stem cells; cancer therapy; cell cycle arrest; glycolysis; in silico modeling; senescence.

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Figure 1. Potential applications of Skp2 inhibitor compound #25. The current study identifies a specific Skp2 inhibitor compound #25 that phenocopies the effect of Skp2 deficiency to target tumorigenesis by upregulation of p27 tumor suppressor and inactivation of Akt oncoprotein. Given that Skp2 loss reduces the number of adipocytes, possibly through p27 accumulation, compound #25 may also be used as a tool for obesity prevention.
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References

    1. Hershko DD. Cancer. 2008;112:1415–24. doi: 10.1002/cncr.23317. - DOI - PubMed
    1. Chen Q, et al. Blood. 2008;111:4690–9. doi: 10.1182/blood-2007-09-112904. - DOI - PMC - PubMed
    1. Wu L, et al. Chem Biol. 2012;19:1515–24. doi: 10.1016/j.chembiol.2012.09.015. - DOI - PMC - PubMed
    1. Chan CH, et al. Cell. 2012;149:1098–111. doi: 10.1016/j.cell.2012.02.065. - DOI - PMC - PubMed
    1. Chan CH, et al. Cell. 2013;154:556–68. doi: 10.1016/j.cell.2013.06.048. - DOI - PMC - PubMed

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