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. 2014 Jan;4(1):42-7.
doi: 10.5415/apallergy.2014.4.1.42. Epub 2014 Jan 31.

Age of onset as a risk factor of renal involvement in Henoch-Schönlein purpura

Reni Ghrahani  1 , Masayu Amanda Ledika  1 , Gartika Sapartini  1 , Budi Setiabudiawan  1
Affiliations

Age of onset as a risk factor of renal involvement in Henoch-Schönlein purpura

Reni Ghrahani et al. Asia Pac Allergy. 2014 Jan.

Abstract

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis in children, characterized by triad of symptoms; palpable purpura without thrombocytopenia, abdominal pain, and arthritis. Renal involvement often occur in children with HSP. No data on the renal involvement of children with HSP in Indonesia, especially West Java.

Objective: To evaluate renal involvement in children with HSP.

Methods: Retrospective study was conducted in children with HSP in Department of Child Health, Hasan Sadikin Hospital, from 2006 to 2011. Characteristics and clinical manifestations was reviewed from medical record. HSP was diagnosed by American College of Rheumatology 1990 criteria or European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society 2008.

Results: There were 128 patients, consisting of 82 male (64.9%) and 46 female (35.1%) with ratio 1.8:1. Mean age was 7.9 ± 2.9 years old which range from 6 month to 15 years. Peak morbidity was between 5-10 years old. Prevalence of HSP in Hasan Sadikin Hospital tend to raise from 2.7/100,000 in 2008 to 5.2/100,000 in 2010. In most patients (71%) purpura was the first symptom. Seventy-one patients (44.5%) had arthritis and 89 patients (69.5%) had abdominal pain, while renal involvement was in 28 patients (21.8%). Gastrointestinal manifestations tend to manifest in patients less than 5 years old (p = 0.267), while renal involvement tend to manifest in age group 11-15 years old (p = 0.015) with odds ratio 3.1 (95% confidence interval, 1.2-8.1).

Conclusion: Renal involvement in children with HSP is more common in age group 11 to 15 years old.

Keywords: Child; Renal involvement; Risk factors; Schoenlein-Henoch purpura.

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Figures

Fig. 1
Fig. 1
Age and sex distribution in 128 children with Henoch-Schönlein purpura.
Fig. 2
Fig. 2
Distribution frequency of Henoch-Schönlein purpura each month.
Fig. 3
Fig. 3
Incidence of Henoch-Schönlein purpura annually.
See this image and copyright information in PMC

References

    1. Gardner-Medwin JM, Dolezalova P, Cummins C, Southwood TR. Incidence of Henoch-Schönlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet. 2002;360:1197–1202. - PubMed
    1. Aalberse J, Dolman K, Ramnath G, Pereira RR, Davin JC. Henoch Schonlein purpura in children: an epidemiological study among Dutch paediatricians on incidence and diagnostic criteria. Ann Rheum Dis. 2007;66:1648–1650. - PMC - PubMed
    1. Reamy BV, Williams PM, Lindsay TJ. Henoch-Schönlein purpura. Am Fam Physician. 2009;80:697–704. - PubMed
    1. Lau KK, Suzuki H, Novak J, Wyatt RJ. Pathogenesis of Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 2010;25:19–26. - PMC - PubMed
    1. Sinclair P. Henoch-schönlein purpura: a review. Curr Allergy Clin Immunol. 2010;23:116–120.

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