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. 1988 May;79(1):18-23.
doi: 10.1007/BF00291703.

Inhibition of condensation in the late-replicating X chromosome induced by 5-azadeoxycytidine in human lymphocyte cultures

T Haaf  1 , G Ott, M Schmid
Affiliations

Inhibition of condensation in the late-replicating X chromosome induced by 5-azadeoxycytidine in human lymphocyte cultures

T Haaf et al. Hum Genet. 1988 May.

Abstract

The cytidine analogue 5-azadeoxycytidine (5-azadC) induces a very distinct inhibition of condensation in the genetically inactive, late-replicating X chromosome (XL) when applied to human lymphocyte cultures. One of the two X chromosomes in cytogenetically normal female cells becomes dramatically longer than its homologous partner. The highest rate of metaphases with an undercondensed XL chromosome is achieved when 5-aza-dC is added at a final concentration of 10(-5) M 2 h before cell harvesting. The interactions between 5-aza-dC and chromosomal DNA as well as the factors involved in X chromosome inactivation are discussed.

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References

    1. Exp Cell Res. 1987 Oct;172(2):481-6 - PubMed
    1. Cell. 1980 May;20(1):85-93 - PubMed
    1. Humangenetik. 1974 Jan 22;21(1):55-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3395-9 - PubMed
    1. Science. 1981 Jun 19;212(4501):1350-7 - PubMed

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