Influenza A virus lures autophagic protein LC3 to budding sites
- PMID: 24528859
- DOI: 10.1016/j.chom.2014.01.014
Influenza A virus lures autophagic protein LC3 to budding sites
Abstract
Autophagy, a cellular degradation pathway, can restrict or assist viral replication. In this issue of Cell Host & Microbe, Beale et al. (2014) report that the influenza virus matrix protein 2 binds to the essential autophagy protein LC3 to presumably transport LC3-conjugated membranes to the cell surface for budding of stable viruses.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability.Cell Host Microbe. 2014 Feb 12;15(2):239-47. doi: 10.1016/j.chom.2014.01.006. Cell Host Microbe. 2014. PMID: 24528869 Free PMC article.
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