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Comment
. 2014 Feb 13;6(3):417-9.
doi: 10.1016/j.celrep.2014.01.035.

Tumor evolution in response to chemotherapy: phenotype versus genotype

Nicholas E Navin  1
Affiliations
Comment

Tumor evolution in response to chemotherapy: phenotype versus genotype

Nicholas E Navin. Cell Rep. .

Abstract

In this issue of Cell Reports, Almendro et al. report one of the first comprehensive studies on the intratumor heterogeneity of cell phenotypes and genotypes before and after chemotherapy in breast cancer. These data challenge the concept of genetic population bottlenecks and suggest that cellular phenotypes play an important role in developing resistance to therapy.

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Figures

Figure 1
Figure 1. Models of Genetic and Phenotypic Diversity in Response to Therapy
(A) Genetically homogenous population with complete response. (B) Genetic population bottleneck and selection of CD44+ phenotypes. (C) No change in genetic diversity after therapy, but phenotypic selection of CD44+ cells.
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