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Review
. 2014 Apr 20:431:185-91.
doi: 10.1016/j.cca.2014.01.019. Epub 2014 Feb 12.

Galectin-3 in cancer

Lin Song  1 , Jian-wu Tang  2 , Lawrence Owusu  3 , Ming-Zhong Sun  3 , Jun Wu  1 , Jun Zhang  1
Affiliations
Review

Galectin-3 in cancer

Lin Song et al. Clin Chim Acta. .

Abstract

Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-3 as well as its potential action mechanism in tumorigenesis in a variety of cancers were summarized and concluded. Gal-3 is gaining its attraction as a potential new biomarker for the diagnosis, treatment and prognosis of certain tumors.

Keywords: Cancer; Expression; Galectin-3 (Gal-3); Location; Mechanism.

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