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. 2014 Jun;48(3):543-9.
doi: 10.1007/s11262-014-1047-y. Epub 2014 Feb 16.

Emergence of genetically variant Hepatitis C virus population in response to increased antiviral drug pressure, Pakistan

Muhammad Ali  1 , Irshad Ur Rehman, Muhammad Idrees
Affiliations

Emergence of genetically variant Hepatitis C virus population in response to increased antiviral drug pressure, Pakistan

Muhammad Ali et al. Virus Genes. 2014 Jun.

Abstract

Mutations in NS5B gene of Hepatitis C virus (HCV) have been reported in patients undergoing antiviral therapy. In the present study, we report emerging clade of HCV-3a in patients administered with IFN plus ribavirin therapy for 24 weeks and having low viral loads (<250 IU/mL). Mutations D/N244E, K304R, N/K307G, Q/T329V, and A338V were found associated with these emerging strains. This distinct HCV could be associated with the increased antiviral drug pressure.

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References

    1. Virol J. 2010 Aug 26;7:203 - PubMed
    1. J Virol. 2009 Jun;83(11):5760-4 - PubMed
    1. BMC Gastroenterol. 2009 Jan 20;9:5 - PubMed
    1. Antimicrob Agents Chemother. 2009 May;53(5):2129-32 - PubMed
    1. J Virol. 2013 Jun;87(11):6172-81 - PubMed

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