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Comment
. 2014 Feb 25;111(8):2866-7.
doi: 10.1073/pnas.1324285111. Epub 2014 Feb 14.

How macrophages ring the inflammation alarm

Marco E Bianchi  1 , Angelo A Manfredi
Affiliations
Comment

How macrophages ring the inflammation alarm

Marco E Bianchi et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: M.E.B. is founder and part-owner of HMGBiotech, a biotech company that specializes in the HMGB1 field.

Figures

Fig. 1.
Fig. 1.
Diagrammatic representation of the pathway for HMGB1 secretion induced by LPS, as proposed by Lu et al. (1). The two subsequent steps, IFN-β secretion on LPS activation of TLR4 and HMGB1 secretion on binding of IFN-β to its own receptor, are distinguished by arrow color.
See this image and copyright information in PMC

Comment on

  • JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
    Lu B, Antoine DJ, Kwan K, Lundbäck P, Wähämaa H, Schierbeck H, Robinson M, Van Zoelen MA, Yang H, Li J, Erlandsson-Harris H, Chavan SS, Wang H, Andersson U, Tracey KJ. Lu B, et al. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3068-73. doi: 10.1073/pnas.1316925111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469805 Free PMC article.

References

    1. Lu B, et al. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. Proc Natl Acad Sci USA. 2014;111:3068–3073. - PMC - PubMed
    1. Celona B, et al. Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output. PLoS Biol. 2011;9(6):e1001086. - PMC - PubMed
    1. Bianchi ME. DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol. 2007;81(1):1–5. - PubMed
    1. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 2002;418(6894):191–195. - PubMed
    1. Andrassy M, et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation. 2008;117(25):3216–3226. - PubMed

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