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Review
. 1987 Nov-Dec;13(6):349-56.

[Antipsychotic efficacy of neuroleptic neuropeptides in schizophrenia. Review of clinical data]

[Article in French]
Affiliations
  • PMID: 2453339
Review

[Antipsychotic efficacy of neuroleptic neuropeptides in schizophrenia. Review of clinical data]

[Article in French]
V M Verhoeven. Encephale. 1987 Nov-Dec.

Abstract

Recently much interest has been shown in the antipsychotic efficacy of neuroleptic-like neuropeptides in schizophrenia. In this article the clinical effects of the non-opioid fragments of gamma-endorphin, the so-called gamma-type endorphins DT gamma E and DE gamma E are reviewed. In addition, preliminary clinical studies of peptides related to cholecystokinin are considered. It is concluded that gamma-type endorphins possess antipsychotic properties in a subgroup of patients who may belong to Type I schizophrenia. With cholecystokinin-related peptides, in particular ceruletide, antipsychotic effects have been reported, which seem to be more or less comparable to those observed with gamma-type endorphins.

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