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Review
. 2014 Jul:52:15-25.
doi: 10.1016/j.biocel.2014.02.004. Epub 2014 Feb 15.

CFTR structure and cystic fibrosis

Natasha Cant  1 , Naomi Pollock  1 , Robert C Ford  2
Affiliations
Review

CFTR structure and cystic fibrosis

Natasha Cant et al. Int J Biochem Cell Biol. 2014 Jul.

Abstract

CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-binding cassette family of membrane proteins. Although almost all members of this family are transporters, CFTR functions as a channel with specificity for anions, in particular chloride and bicarbonate. In this review we look at what is known about CFTR structure and function within the context of the ATP-binding cassette family. We also review current strategies aimed at obtaining the high resolution structure of the protein.

Keywords: CFTR; Cystic fibrosis; Ion channel; Membrane protein; Protein structure.

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