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. 2014 Mar;8(1):133-40.
doi: 10.1007/s11682-013-9268-6.

It is unclear if adjusting cortical thickness for changes in gray/white matter intensity ratio improves discrimination between normal aging, MCI, and AD

Corinna M Bauer  1 , Howard J Cabral, Ronald J Killiany; Alzheimer’s Disease Neuroimaging Initiative
Affiliations

It is unclear if adjusting cortical thickness for changes in gray/white matter intensity ratio improves discrimination between normal aging, MCI, and AD

Corinna M Bauer et al. Brain Imaging Behav. 2014 Mar.

Abstract

The contrast between gray and white matter in MRI is critical for accurately measuring cortical thickness. The gray/white matter intensity ratio (GWIR) has been proposed to be an important adjustment factor for cortical thickness measures in Alzheimer's disease (AD) and mild cognitive impairment (MCI). This study examined the GWIR and its influence on cortical thickness in normal aging, mild cognitive impairment (MCI), and AD. The ability for GWIR to discriminate between these groups was assessed on its own and as an adjustment factor for cortical thickness. Minimal age- and AD-related changes in GWIR were observed. GWIR was not able to differentiate between normal aging, MCI, and AD. However, adjusting cortical thickness for GWIR slightly improved the ability to discriminate between groups and the effect size of cortical thickness increased after adjusting for GWIR. This work demonstrates the ambiguity in adjusting cortical thickness measures for GWIR, particularly when attempting to discriminate between normal aging, MCI, and AD groups.

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Conflict of interest statement

Disclosure statement

The authors have no actual or potential conflicts of interest to disclose.

Figures

Figure 1
Figure 1
ROC curve for discriminating between AD and normal aging highlighting the effects of adjusting cortical thickness for GWIR. Blue solid line represents cortical thickness, white dotted red line represents GWIR adjusted cortical thickness.
See this image and copyright information in PMC

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