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. 2014 Feb;16(2):393.
doi: 10.1007/s11908-014-0393-1.

Bones, Fractures, Antiretroviral Therapy and HIV

Linda A Battalora  1 , Benjamin Young, Edgar T Overton
Affiliations

Bones, Fractures, Antiretroviral Therapy and HIV

Linda A Battalora et al. Curr Infect Dis Rep. 2014 Feb.

Abstract

The course of HIV infection has been dramatically transformed by the success of antiretroviral therapy from a universally fatal infection to a manageable chronic disease. With these advances in HIV disease management, age-related comorbidities, including metabolic bone disease, have become more prominent in the routine care of persons living with HIV infection. Recent data have highlighted the role of HIV infection, initiation of antiretroviral therapy, and hepatitis C virus coinfection in bone mineral density loss and fracture incidence. Additionally, the underlying mechanism for the development of metabolic bone disease in the setting of HIV infection has received considerable attention. This review highlights recently published and presented data and synthesizes the current state of the field. These data highlight the need for proactive prevention for fragility fractures.

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Conflict of interest statement

Conflict of Interest

Edgar T. Overton was a consultant for Gliead Science and Janssen. Edgar T. Overton received a grant from Vertex Pharmaceuticals. Linda A. Battalora has no conflicts. Ben Young was a consultant for Gilead Sciences, Merck & Co, Viiv Healthcare and Bristol-Meyers Squibb. Ben Young received honoraria from Merck & Co, Viiv Healthcare, Gilead Sciences, Monogram Biosciences and Bristol-Meyers Squibb. Ben Young received payment for development of educational presentations from Viiv Healthcare.

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