Three-dimensional volumetric quantification of fat loss following cryolipolysis

Abstract

Background and objectives: Cryolipolysis is a noninvasive and well-tolerated treatment for reduction of localized subcutaneous fat. Although several studies demonstrate the safety and efficacy of this procedure, volumetric fat reduction from this treatment has not been quantified. This prospective study investigated the change in volume of fat after cryolipolysis treatment using three-dimensional (3D) photography.

Materials and methods: A prospective study of subjects treated with cryolipolysis on the flank (love handle) was performed at Massachusetts General Hospital. Volume measurements were performed with a Canfield Scientific Vectra three-dimensional camera and software to evaluate the amount of post procedure volume change. Clinical outcomes were assessed with caliper measurements, subject surveys, and blinded physician assessment of photographs.

Results: Eleven subjects were enrolled in this study. Each subject underwent a single cycle of cryolipolysis to one flank. The untreated flank served as an internal control. The follow-up time after treatment was 2 months. The mean amount of calculated absolute fat volume loss using 3D photography from baseline to 2 months follow-up visit was 56.2 ± 25.6 from the treatment site and 16.6 ± 17.6 cc from the control (P < 0.0001). A mean absolute difference of 39.6 cc between the treated and untreated sides was calculated at 2 months post-treatment. Comparison of caliper measurements from baseline to 2 months post-treatment demonstrated significant reduction of the treated flank from 45.6 ± 5.8 mm at baseline to 38.6 ± 4.6 mm at 2 months post-treatment (P < 0.001). The untreated flank did not show significant reduction with caliper measurements demonstrating 45.3 ± 5.0 mm at baseline and 44.6 ± 5.1 mm at 2 months post-treatment (P = 0.360). No unexpected side effects or adverse events were reported. Post-treatment satisfaction surveys demonstrated 82% of subjects were satisfied with the results.

Conclusions: Cryolipolysis is a safe, well-tolerated, and effective noninvasive fat removal methodology that on average leads to 39.6 cc of fat loss of the treated flank at 2 months after a single treatment cycle.

Keywords: cold induced fat loss; fat removal; imaging; noninvasive; volume of fat.

Figure 1

Quantification of volume loss. Three-dimensional imaging system software was used to quantify volume loss for treated and control (untreated) sites from baseline to 2 month follow up. **p<0.0001

Figure 2

Caliper measurements of treated and control (untreated) at baseline and at 2 months post-treatment follow up.

Figure 3

Weight measurements of all subjects at baseline and at 2 month follow up.

Figure 4

Flanks (love handles) at baseline and at 2 month follow up after a single treatment. The left flank was treated and the right flank was a control (untreated).

Figure 5

Three-dimensional colorimetric map colorimetric map of volume change in treated side. Cool colors represent volume loss and warmer colors represent volume gain as distance in mm between flanks. Green represents no change in volume