Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2014 Feb 18;110(4):1088-100.
doi: 10.1038/bjc.2013.769.

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

D Agarwal, S Pineda, K Michailidou, J Herranz, G Pita, L T Moreno, M R Alonso, J Dennis, Q Wang, M K Bolla, K B Meyer, P Menéndez-Rodríguez, D Hardisson, M Mendiola, A González-Neira, A Lindblom, S Margolin, A Swerdlow, A Ashworth, N Orr, M Jones, K Matsuo, H Ito, H Iwata, N Kondo; kConFab Investigators; Australian Ovarian Cancer Study Group; M Hartman, M Hui, W Y Lim, P T -C Iau, E Sawyer, I Tomlinson, M Kerin, N Miller, D Kang, J -Y Choi, S K Park, D -Y Noh, J L Hopper, D F Schmidt, E Makalic, M C Southey, S H Teo, C H Yip, K Sivanandan, W -T Tay, H Brauch, T Brüning, U Hamann; GENICA Network; A M Dunning, M Shah, I L Andrulis, J A Knight, G Glendon, S Tchatchou, M K Schmidt, A Broeks, E H Rosenberg, L J van't Veer, P A Fasching, S P Renner, A B Ekici, M W Beckmann, C -Y Shen, C -N Hsiung, J -C Yu, M -F Hou, W Blot, Q Cai, A H Wu, C -C Tseng, D Van Den Berg, D O Stram, A Cox, I W Brock, M W R Reed, K Muir, A Lophatananon, S Stewart-Brown, P Siriwanarangsan, W Zheng, S Deming-Halverson, M J Shrubsole, J Long, X -O Shu, W Lu, Y -T Gao, B Zhang, P Radice, P Peterlongo, S Manoukian, F Mariette, S Sangrajrang, J McKay, F J Couch, A E Toland; TNBCC; D Yannoukakos, O Fletcher, N Johnson, I dos Santos Silva, J Peto, F Marme, B Burwinkel, P Guénel, T Truong, M Sanchez, C Mulot, S E Bojesen, B G Nordestgaard, H Flyer, H Brenner, A K Dieffenbach, V Arndt, C Stegmaier, A Mannermaa, V Kataja, V -M Kosma, J M Hartikainen, D Lambrechts, B T Yesilyurt, G Floris, K Leunen, J Chang-Claude, A Rudolph, P Seibold, D Flesch-Janys, X Wang, J E Olson, C Vachon, K Purrington, G G Giles, G Severi, L Baglietto, C A Haiman, B E Henderson, F Schumacher, L Le Marchand, J Simard, M Dumont, M S Goldberg, F Labréche, R Winqvist, K Pylkäs, A Jukkola-Vuorinen, M Grip, P Devilee, R A E M Tollenaar, C Seynaeve, M García-Closas, S J Chanock, J Lissowska, J D Figueroa, K Czene, M Eriksson, K Humphreys, H Darabi, M J Hooning, M Kriege, J M Collée, M Tilanus-Linthorst, J Li, A Jakubowska, J Lubinski, K Jaworska-Bieniek, K Durda, H Nevanlinna, T A Muranen, K Aittomäki, C Blomqvist, N Bogdanova, T Dörk, P Hall, G Chenevix-Trench, D F Easton, P D P Pharroah, J I Arias-Perez, P Zamora, J Benítez, R L Milne
Collaborators
Multicenter Study

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

D Agarwal et al. Br J Cancer. .

Abstract

Background: Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.

Methods: Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.

Results: Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.

Conclusion: Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

PubMed Disclaimer

References

    1. Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Morrison J, Maranian M, Pooley KA, Luben R, Eccles D, Evans DG, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Stratton MR, Rahman N, Jacobs K, Prentice R, Anderson GL, Rajkovic A, Curb JD, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Diver WR, Bojesen S, Nordestgaard BG, Flyger H, Dork T, Schurmann P, Hillemanns P, Karstens JH, Bogdanova NV, Antonenkova NN, Zalutsky IV, Bermisheva M, Fedorova S, Khusnutdinova E, Kang D, Yoo KY, Noh DY, Ahn SH, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Garcia-Closas M, Lissowska J, Brinton L, Peplonska B, Nevanlinna H, Heikkinen T, Aittomaki K, Blomqvist C, Hopper JL, Southey MC, Smith L, Spurdle AB, Schmidt MK, Broeks A, van Hien RR, Cornelissen S, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Schmutzler RK, Burwinkel B, Bartram CR, Meindl A, Brauch H, Justenhoven C, Hamann U, Chang-Claude J, Hein R, Wang-Gohrke S, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Kataja V, Olson JE, Wang X, Fredericksen Z, Giles GG, Severi G, Baglietto L, English DR, Hankinson SE, Cox DG, Kraft P, Vatten LJ, Hveem K, Kumle M, Sigurdson A, Doody M, Bhatti P, Alexander BH, Hooning MJ, van den Ouweland AM, Oldenburg RA, Schutte M, Hall P, Czene K, Liu J, Li Y, Cox A, Elliott G, Brock I, Reed MW, Shen CY, Yu JC, Hsu GC, Chen ST, Anton-Culver H, Ziogas A, Andrulis IL, Knight JA, Beesley J, Goode EL, Couch F, Chenevix-Trench G, Hoover RN, Ponder BA, Hunter DJ, Pharoah PD, Dunning AM, Chanock SJ, Easton DF. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet. 2009;41:585–590. - PMC - PubMed
    1. Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjakoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet. 2003;72:1117–1130. - PMC - PubMed
    1. Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, Sinilnikova OM, Healey S, Morrison J, Kartsonaki C, Lesnick T, Ghoussaini M, Barrowdale D, Peock S, Cook M, Oliver C, Frost D, Eccles D, Evans DG, Eeles R, Izatt L, Chu C, Douglas F, Paterson J, Stoppa-Lyonnet D, Houdayer C, Mazoyer S, Giraud S, Lasset C, Remenieras A, Caron O, Hardouin A, Berthet P, Hogervorst FB, Rookus MA, Jager A, van den Ouweland A, Hoogerbrugge N, van der Luijt RB, Meijers-Heijboer H, Gomez Garcia EB, Devilee P, Vreeswijk MP, Lubinski J, Jakubowska A, Gronwald J, Huzarski T, Byrski T, Gorski B, Cybulski C, Spurdle AB, Holland H, Goldgar DE, John EM, Hopper JL, Southey M, Buys SS, Daly MB, Terry MB, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Preisler-Adams S, Arnold N, Niederacher D, Sutter C, Domchek SM, Nathanson KL, Rebbeck T, Blum JL, Piedmonte M, Rodriguez GC, Wakeley K, Boggess JF, Basil J, Blank SV, Friedman E, Kaufman B, Laitman Y, Milgrom R, Andrulis IL, Glendon G, Ozcelik H, Kirchhoff T, Vijai J, Gaudet MM, Altshuler D, Guiducci C, Loman N, Harbst K, Rantala J, Ehrencrona H, Gerdes AM, Thomassen M, Sunde L, Peterlongo P, Manoukian S, Bonanni B, Viel A, Radice P, Caldes T, de la Hoya M, Singer CF, Fink-Retter A, Greene MH, Mai PL, Loud JT, Guidugli L, Lindor NM, Hansen TV, Nielsen FC, Blanco I, Lazaro C, Garber J, Ramus SJ, Gayther SA, Phelan C, Narod S, Szabo CI, Benitez J, Osorio A, Nevanlinna H, Heikkinen T, Caligo MA, Beattie MS, Hamann U, Godwin AK, Montagna M, Casella C, Neuhausen SL, Karlan BY, Tung N, Toland AE, Weitzel J, Olopade O, Simard J, Soucy P, Rubinstein WS, Arason A, Rennert G, Martin NG, Montgomery GW, Chang-Claude J, Flesch-Janys D, Brauch H, Severi G, Baglietto L, Cox A, Cross SS, Miron P, Gerty SM, Tapper W, Yannoukakos D, Fountzilas G, Fasching PA, Beckmann MW, Dos Santos Silva I, Peto J, Lambrechts D, Paridaens R, Rudiger T, Forsti A, Winqvist R, Pylkas K, Diasio RB, Lee AM, Eckel-Passow J, Vachon C, Blows F, Driver K, Dunning A, Pharoah PP, Offit K, Pankratz VS, Hakonarson H, Chenevix-Trench G, Easton DF, Couch FJ. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet. 2010;42:885–892. - PMC - PubMed
    1. Aulchenko YS, Ripke S, Isaacs A, van Duijn CM. GenABEL: an R library for genome-wide association analysis. Bioinformatics. 2007;23:1294–1296. - PubMed
    1. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265. - PubMed

Publication types

MeSH terms

Substances

Grants and funding