Self-gratification yields not-so-naive T cells

Affiliations

¹ Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Kellogg School of Science and Technology Doctoral Program in Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, California, USA.
² Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea, the Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea.

Comment

Christopher E Martin et al. Nat Immunol. 2014 Mar.

. 2014 Mar;15(3):217-9.

doi: 10.1038/ni.2832.

¹ Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Kellogg School of Science and Technology Doctoral Program in Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, California, USA.
² Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea, the Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea.

No abstract available

Comment on

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC.
Persaud SP, Parker CR, Lo WL, Weber KS, Allen PM. Persaud SP, et al. Nat Immunol. 2014 Mar;15(3):266-74. doi: 10.1038/ni.2822. Epub 2014 Feb 2. Nat Immunol. 2014. PMID: 24487322 Free PMC article.