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. 1988 Apr;79(4):529-37.
doi: 10.1111/j.1349-7006.1988.tb01623.x.

Measurement by leukocyte adherence inhibition of autosensitization of cancer patients to myelin basic protein

Z Gouda  1 , D M Thomson
Affiliations

Measurement by leukocyte adherence inhibition of autosensitization of cancer patients to myelin basic protein

Z Gouda et al. Jpn J Cancer Res. 1988 Apr.

Abstract

In vitro cell-mediated immunity was assayed by leukocyte adherence inhibition (LAI) to determine the extent of autosensitization to myelin basic protein (MBP). Leukocytes from 123 cancer patients, 16 patients freed of cancer, 135 patients with benign disease, and 26 patients with destruction of nervous parenchyma were tested. Most patients with cancer reacted to MBP: 92%, 93%, 82%, 78%, 75% and 62% for pancreatic, colonic, esophageal, lung, ovarian and breast. Few patients with benign diseases reacted to MBP. Patients with multiple sclerosis (MS) were sensitized to MBP, but patients with other nervous tissue injury did not react to MBP. Cancer patients did not remain sensitized to MBP once they were freed of their cancer. The LAI assay is a straightforward method of measuring cellular autosensitivity to MBP. In the population of patients tested, autosensitivity to MBP was confined, except for MS, principally to cancer patients.

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References

    1. ) Hewitt , H. B. , Blake , E. R. and Walder , A. S.A critique of the evidence for active host defense against cancer, based on personal studies of 27 murine tumors of spontaneous origin . Br. J. Cancer 33 , 241 – 259 ( 1976. ). - PMC - PubMed
    1. ) Boon , T.Antigenic tumor cell variants obtained with mutagens . Adv. Cancer Res. 39 , 121 – 151 ( 1983. ). - PubMed
    1. ) Van Pel , A. , Vessière , F. and Boon , T.Protection against two spontaneous mouse leu‐kemias conferred by immunogenic variants obtained by mutagenesis . J. Exp. Med. , 157 , 1992 – 2001 ( 1983. ). - PMC - PubMed
    1. ) McBride , W. H. and Howie , S. E. M.Induction of tolerance to a murine fibrosarcoma in two zones of dosage ‐ the involvement of suppressor cells . Br. J. Cancer 53 , 707 – 711 ( 1986. ). - PMC - PubMed
    1. ) Muul , L. M. , Spiess , P. J. , Director , E. P. and Rosenberg , S. A.Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma . J. Immunol. 138 , 989 – 995 ( 1987. ). - PubMed

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