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. 2012 Oct;1(5):207-10.
doi: 10.1002/open.201200023. Epub 2012 Sep 28.

A platform for specific delivery of lanthanide-scandium mixed-metal cluster fullerenes into target cells

Anna Svitova  1 , Klaus Braun  2 , Alexey A Popov  1 , Lothar Dunsch  1
Affiliations

A platform for specific delivery of lanthanide-scandium mixed-metal cluster fullerenes into target cells

Anna Svitova et al. ChemistryOpen. 2012 Oct.
No abstract available

Keywords: bioshuttles; gadolinium; molecular imaging; nitride cluster fullerenes.

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Figures

Figure 1
Figure 1
A) Chromatogram of GdxSc3−xN@C2n fullerene extract mixture synthesized by the arc burning method (combination of two 4.6×250 mm Buckyprep columns; flow rate of 1.6 mL min−1; toluene as eluent; 40 °C), molecular structures of GdSc2N@C80 (I) and Gd2ScN@C80 (I) are shown. B) Positive-ion MALDI-TOF MS of the major HPLC fraction collected at tR=29.8–32.0 min; insets show the isotopic patterns of GdSc2N@C80 and Gd2ScN@C80.
Figure 2
Figure 2
Modular structure of the c-myc-antisense-Gd@BioShuttle conjugate: The module cell-penetrating peptide (CPP) (green) is connected via the cleavable disulfide bridge (yellow) to the address module (c-myc antisense PNA; exon II) (ocher), which in turn is ligated covalently with the imaging component as a cargo via a lysine spacer (blue). The fluorescence dye is coupled to the ε-amino group of the lysine.
Figure 3
Figure 3
CLSM study of the transport of Alexa Fluor® 546-labeled c-myc- antisense Gd@BioShuttle into c-myc mRNA-positive human prostate cancer cells DU145. Incubation time was increased from 5 to 30 min. Excitation wavelength: 543 nm; emission detection window: 572–650 nm.
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