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. 2013 Dec;7(12):2694-6.
doi: 10.7860/JCDR/2013/7592.3734. Epub 2013 Nov 25.

Cardiovascular disease risk in schizophrenia patients: a case control study

Kedar B Joshi  1 , Anup Nillawar  2 , A P Thorat  3
Affiliations

Cardiovascular disease risk in schizophrenia patients: a case control study

Kedar B Joshi et al. J Clin Diagn Res. 2013 Dec.

Abstract

Background: The Schizophrenia patients are at higher risk for cardiovascular morbidity and mortality. The aim of this case-control study is to measure Cardiovascular Disease (CVD) risk parameters in patient group and compare it with normal population.

Methodology: We recruited 45 cases of Schizophrenia diagnosed by diagnostic and statistical manual of mental disorders (DSM-IV) criteria and 41 healthy controls from general population. The body mass index, metabolic syndrome parameters, lipid parameters and high sensitive C-reactive protein were measured in both groups. Metabolic syndrome and dyslipidemia prevalence were assessed based on National Cholesterol Education Programme (NCEP) Adult Treatment Panel III (ATP III) guidelines.

Results: The Schizophrenia subjects showed statistically significant high waist circumference, increased triglycerides and decreased HDL cholesterol values. The subjects also showed statistically significant increased hs-CRP values. The prevalence of metabolic syndrome and laboratory dyslipidemia were 28.8% and 51.1% respectively, which were higher compared to control group.

Conclusion: The Schizophrenia subjects are at higher risk for cardiovascular disease events due to high prevalence of metabolic syndrome and dyslipidemia. These patients should be regularly monitored for CVD risk factors and timely referred to physician for further management.

Keywords: Dyslipidemia; HS-CRP; Metabolic Syndrome.

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References

    1. Wig NN, Varma Vijoy K, Mattoo SK, Behere PB, Phookan HR, Misra AK, et al. An incidence study of Schizophrenia in India. Indian J Psychiatry. 1993 Jan-Mar;35(1):11–17. - PMC - PubMed
    1. McGrath J, et al. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev. 2008;30:67–76. - PubMed
    1. Sperling W, Biermann T. Mortality in patients with Schizophrenia. Lancet. 2009;374(9701):1592. author reply 1592–3. - PubMed
    1. Tiihonen J, et al. 11-year follow-up of mortality in patients with Schizophrenia: a population-based cohort study (FIN11 study) Lancet. 2009;374(9690):620–27. - PubMed
    1. Leucht S, Burkard T, Henderson J, Maj M, Sartorius N. Physical illness and Schizophrenia: a review of the literature. Acta Psychiatr Scand. 2007;116(5):317–33. - PubMed

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