Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Fall;1(4):191-6.

Central effects of camphor on GnRH and sexual hormones in male rat

Sima Shahabi  1 , Seyed Gholam Ali Jorsaraei  2 , Ali Akbar Moghadamnia  1 , Ebrahim Zabihi  1 , Seyed Mohsen Aghajanpour  3 , Seyedeh Narges Mousavi Kani  3 , Roghieh Pourbagher  3 , Seyed Ahmad Hosseini  4 , Mohsen Esmaili  4 , Ali Asghar Yoonesi  4 , Amin Zarghami  4 , Farid Alinezhad  4
Affiliations

Central effects of camphor on GnRH and sexual hormones in male rat

Sima Shahabi et al. Int J Mol Cell Med. 2012 Fall.

Abstract

In Persian traditional medicine is believed that camphor (a crystalline ketone obtained from cinnamomum camphora) is a suppressor of sexual behaviors. This study examined the central effects of camphor on sexual hormones (LH, FSH and testosterone) and GnRH plasma levels in male rat. Male Wistar rats weighing 250-260gr were selected and divided into control (no treatment), sham (ICV injection of EtOH 10%) and treatment (ICV injection of camphor in three doses 4, 20, 40 µg/ 10µl in alcohol) groups. The serum samples were used for assaying of GnRH, LH, FSH and testosterone. There were no significant differences in the levels of hormones between the groups of study. Despite the central administration of camphor in hypothalamus - pituitary - gonad (HPG) axis, no significant differences were seen in sex hormone`s levels compared to the control. With this finding, it can be concluded that camphor may not effectively handle the axis via central pathway. These data recommend further studies of camphor on the HPG axis.

Keywords: Camphor; GnRH; Hypothalamus - Pituitary - Gonad (H-P-G) Axis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Osawa H, Endo I, Hara Y, et al. Transient proliferation of proanthocyanidin-accumulating cells on the epidermal apex contributes to highly aluminum-resistant root elongation in camphor tree. Plant Physiol. 2011;155:433–46. - PMC - PubMed
    1. Azadbakht M. Classification of Medicinal Plants. Tehran: Taimourzadeh; 1999. [Book in persian]
    1. Guilbert J, Flamant C, Hallalel F, et al. Anti-flatulence treatment and status epilepticus: a case of camphor intoxication. Emerg Med J. 2007;24:859–60. - PMC - PubMed
    1. http://www.usp.org/pdf/EN/referenceStandards/msds/1087508.pdf.
    1. Manoguerra AS, Erdman AR, Wax PM, et al. Camphor Poisoning: an evidence-based practice guideline for out-of-hospital management. Clin Toxicol. 2006;44:357–70. - PubMed

LinkOut - more resources