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. 2013 Fall;2(4):185-93.

p53 and PCNA Expression in Keratocystic Odontogenic Tumors Compared with Selected Odontogenic Cysts

Maryam Seyedmajidi  1 , Shima Nafarzadeh  2 , Sepideh Siadati  3 , Shahryar Shafaee  4 , Ali Bijani  5 , Nazanin Keshmiri  6
Affiliations

p53 and PCNA Expression in Keratocystic Odontogenic Tumors Compared with Selected Odontogenic Cysts

Maryam Seyedmajidi et al. Int J Mol Cell Med. 2013 Fall.

Abstract

p53 and PCNA expression in keratocystic odontogenic tumors compared with selected odontogenic cysts Summary: The aim of this study was to evaluate p53 and PCNA expression in different odontogenic lesions regarding their different clinical behaviors. Slices prepared from 94 paraffin-embedded tissue blocks (25 radicular cysts (RC), 23 dentigerous cysts (DC), 23 keratocystic odontogenic tumors (KCOT) and 23 calcifying cystic odontogenic tumors (CCOT)) were stained with p53 and PCNA antibodies using immunohistochemistry procedure. The highest level of p53 expression was in the basal layer of RC, and the highest level of PCNA expression was in the suprabasal layer of KCOT. The differences of p53 expression in basal and suprabasal layers as well as PCNA expression in the suprabasal layer were significant but there was no significant difference in PCNA expression in the basal layer of these lesions. The expression of p53 in the basal layer of RC was higher than in other cysts. This may be due to intensive inflammatory infiltration. Also, the high level of PCNA expression in the suprabasal layer of KCOT may justify its neoplastic nature and tendency to recurrence. KCOT and calcifying cystic odontogenic tumors did not show similar expression of studied biomarkers.

Keywords: PCNA; calcifying cystic odontogenic tumor; dentigerous cyst; keratocystic odontogenic tumor; p53; radicular cyst.

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Figures

Chart 1
Chart 1
p53 and PCNA expression in basal and suprabasal layers in different odontogenic cysts
Fig 1
Fig 1
Immunohistochemical expression of p53 (A) and PCNA (B) in radicular cyst (400X).
Fig 2
Fig 2
Immunohistochemical expression of p53 (A) and PCNA (B) in keratocystic odontogenic tumor (400X).
Fig 3
Fig 3
Immunohistochemical expression of p53 (A) and PCNA (B) in calcifying cystic odontogenic tumor (400X).
Fig 4
Fig 4
Immunohistochemical expression of p53 (A) and PCNA (B) in dentigerous cyst (400X) (400X).
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