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Review
. 2014 Mar;15(3):181-92.
doi: 10.1038/nrn3677.

Hippocampal synaptic plasticity, spatial memory and anxiety

David M Bannerman  1 , Rolf Sprengel  2 , David J Sanderson  3 , Stephen B McHugh  1 , J Nicholas P Rawlins  1 , Hannah Monyer  4 , Peter H Seeburg  2
Affiliations
Free article
Review

Hippocampal synaptic plasticity, spatial memory and anxiety

David M Bannerman et al. Nat Rev Neurosci. 2014 Mar.
Free article

Abstract

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

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