Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Mar;15(3):181-92.
doi: 10.1038/nrn3677.

Hippocampal synaptic plasticity, spatial memory and anxiety

David M Bannerman  1 , Rolf Sprengel  2 , David J Sanderson  3 , Stephen B McHugh  1 , J Nicholas P Rawlins  1 , Hannah Monyer  4 , Peter H Seeburg  2
Affiliations
Free article
Review

Hippocampal synaptic plasticity, spatial memory and anxiety

David M Bannerman et al. Nat Rev Neurosci. 2014 Mar.
Free article

Abstract

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

PubMed Disclaimer

References

    1. Adv Exp Med Biol. 1986;203:67-82 - PubMed
    1. Nat Neurosci. 2012 Jul 15;15(8):1153-9 - PubMed
    1. Psychol Bull. 1967 Jun;67(6):416-22 - PubMed
    1. J Comp Physiol Psychol. 1965 Feb;59:137-40 - PubMed
    1. Neuron. 2005 Jun 2;46(5):703-13 - PubMed

Publication types

Substances