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. 2014 Jan-Feb;56(1):67-9.
doi: 10.1590/S0036-46652014000100010.

First report of metallo-β-lactamases producing Enterobacter spp. strains from Venezuela

Dianny Martínez  1 , Hectorina E Rodulfo  1 , Lucy Rodríguez  2 , Luisa E Caña  2 , Belkis Medina  2 , Militza Guzman  3 , Numirin Carreño  1 , Daniel Marcano  4 , Marcos De Donato  1
Affiliations

First report of metallo-β-lactamases producing Enterobacter spp. strains from Venezuela

Dianny Martínez et al. Rev Inst Med Trop Sao Paulo. 2014 Jan-Feb.

Abstract
in English, Spanish

Clinical strains of Enterobacter were isolated from Cumana's Central Hospital in Venezuela, and classified as E. cloacae (21), E. aerogenes (7), E. intermedium (1), E. sakazakii (1) and three unclassified. The strains showed high levels of resistance, especially to SXT (58.1%), CRO (48.8%), CAZ (46.6%), PIP (46.4%), CIP (45.2%) and ATM (43.3%). This is the first report for South America of blaVIM-2 in two E. cloacae and one Enterobacter sp., which also showed multiple mechanisms of resistance. Both E. cloacae showed blaTEM-1, but only one showed blaCTX-M-15 gene, while no blaSHV was detected.

Cepas clínicas de Enterobacter fueron aisladas del Hospital central de Cumaná en Venezuela, y se clasificaron como E. cloacae (21), E. aerogenes (7), E. intermedium (1), E. sakazakii (1) y 3 sin clasificar. Las cepas mostraron altos niveles de resistencia, especialmente a SXT (58.1%), CRO (48.8%), CAZ (46.6%), PIP (46.4%), CIP (45.2%) and ATM (43.3%). Este es el primer reporte de América del Sur de bla VIM-2 en dos cepas de E. cloacae y una de Enterobacter sp., las cuales también mostraron múltiples mecanismos de resistencia. Ambas especies de E. cloacae mostraron genes bla TEM-1, pero solo una mostro el gen bla CTX-M-15, mientras que bla SHV no fue detectado.

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Figures

Fig. 1
Fig. 1. Antimicrobial susceptibility of the Enterobacter strains isolated in the Cumana hospital of Venezuela. CAZ: ceftazidime, CRO: ceftriaxone, FEP: cefepime, ATM: aztreonam, IPM: imipenem, MER: meropenem, PIP: piperacillin, TZP: piperacillin/tazobactam, SXT: trimethoprim-sulfamethoxazole, GM: gentamicin, AK: amikacin, CIP: ciprofloxacin and TGC: tigecycline.
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References

    1. Betriu C, Rodríguez-Avial I, Gómez M, Culebras E, López F, Alvarez J, et al. Antimicrobial activity of tygecicline against clinical isolates from Spanish medical centers. Second multicenter study. Diagn Microbiol Infect Dis. 2006;56:437–444. - PubMed
    1. Falcone M, Mezzatesta ML, Perilli M, Forcella C, Giordano A, Cafiso V, et al. Infections with VIM-1 metallo-beta-lactamase-producing Enterobacter cloacae and their correlation with clinical outcome. J Clin Microbiol. 2009;47:3514–3519. - PMC - PubMed
    1. Fiett J, Baraniak A, Mrówka A, Fleischer M, Drulis-Kawa Z, Naumiuk Ł, et al. Molecular epidemiology of acquired-metallo-beta-lactamase-producing bacteria in Poland. Antimicrob Agents Chemother. 2006;50:880–886. - PMC - PubMed
    1. Gomez S, Rapoport M, Togneri A, Viegas-Caetano J, Faccone D, Corso A, et al. Emergence of metallo-β-lactamases in Enterobacteriaceae from Argentina. Diagn Microbiol Infect Dis. 2011;69:94–97. - PubMed
    1. Guevara A, Waard J de, Araque M. Detección del gen blaVIM-2 en cepas de Pseudomonas aeruginosa productoras de metalo β-lactamasa aisladas en una unidad de cuidados intensivos en Ciudad Bolívar, Venezuela. Rev Chil Infect. 2009;26:336–341. - PubMed

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