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. 2014 Mar;102(3):245-52.
doi: 10.5935/abc.20140003. Epub 2014 Feb 10.

Echocardiographic parameters and survival in Chagas heart disease with severe systolic dysfunction

[Article in English, Portuguese]
Daniela do Carmo Rassi  1 , Marcelo Luiz Campos Vieira  2 , Ana Lúcia Martins Arruda  3 , Viviane Tiemi Hotta  2 , Rogério Gomes Furtado  1 , Danilo Teixeira Rassi  1 , Salvador Rassi  1
Affiliations

Echocardiographic parameters and survival in Chagas heart disease with severe systolic dysfunction

[Article in English, Portuguese]
Daniela do Carmo Rassi et al. Arq Bras Cardiol. 2014 Mar.

Abstract

Background: Echocardiography provides important information on the cardiac evaluation of patients with heart failure. The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis.

Objective: To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%.

Methods: Study with retrospective analysis of pre-specified echocardiographic parameters prospectively collected from 60 patients included in the Multicenter Randomized Trial of Cell Therapy in Patients with Heart Diseases (Estudo Multicêntrico Randomizado de Terapia Celular em Cardiopatias) - Chagas heart disease arm. The following parameters were collected: left ventricular systolic and diastolic diameters and volumes; ejection fraction; left atrial diameter; left atrial volume; indexed left atrial volume; systolic pulmonary artery pressure; integral of the aortic flow velocity; myocardial performance index; rate of increase of left ventricular pressure; isovolumic relaxation time; E, A, Em, Am and Sm wave velocities; E wave deceleration time; E/A and E/Em ratios; and mitral regurgitation.

Results: In the mean 24.18-month follow-up, 27 patients died. The mean ejection fraction was 26.6 ± 5.34%. In the multivariate analysis, the parameters ejection fraction (HR = 1.114; p = 0.3704), indexed left atrial volume (HR = 1.033; p < 0.0001) and E/Em ratio (HR = 0.95; p = 0.1261) were excluded. The indexed left atrial volume was an independent predictor in relation to the endpoint, and values > 70.71 mL/m2 were associated with a significant increase in mortality (log rank p < 0.0001).

Conclusion: The indexed left atrial volume was the only independent predictor of mortality in this population of Chagasic patients with severe systolic dysfunction.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Kapplan-Meier curve with analysis of overall survival in the study population
Figure 2
Figure 2
Relationship between survival and Indexed Left Atrial Volume (LAV /m2)
Figure 3
Figure 3
ROC curve of the indexed left atrial volume
See this image and copyright information in PMC

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