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. 2014 Feb;29(1):38-44.
doi: 10.1177/1533317513505131.

Serum folic acid and RFC A80G polymorphism in Alzheimer's disease and vascular dementia

Nasim Mansoori  1 , Manjari Tripathi, Rizwan Alam, Kalpana Luthra, Sumit Sharma, Ramakrishnan Lakshmy, Mani Kalaivani, Asok K Mukhopadhyay
Affiliations

Serum folic acid and RFC A80G polymorphism in Alzheimer's disease and vascular dementia

Nasim Mansoori et al. Am J Alzheimers Dis Other Demen. 2014 Feb.

Abstract

Low level of vitamin B12 and folic acid has been reported to play an important role in the pathogenesis of Alzheimer's disease (AD) and vascular dementia (VaD). Serum folic acid and vitamin B12 were assayed in 80 AD and 50 VaD cases and in 120 healthy controls. The reduced folate carrier (RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction-restriction fragment length polymorphism. It was observed that the patients having folic acid <8.45 ng/mL had 2.4 (95% confidence interval [CI]: 1.4-4.5) times higher odds of having AD and 2.1 (95% CI: 1.1-4.2) times higher odds of having VaD than patients having folic acid ≥8.45 ng/mL. Serum vitamin B12 level did not show any such statistically significant effect in altering the odds. No direct association was found between variant (G) allele or genotype of rs1051266 with AD and VaD cases. On serum folate level no association was observed with gene polymorphism.

Keywords: Alzheimer’s disease; RFC A80G; folic acid; polymorphism; vascular dementia; vitamin B12.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Edmonds ZV. Nutrition and Alzheimer’s disease: the role of folate and vitamin B. Nutrition Bytes. 1999;5(2). http://escholarship.org/uc/item/89g6w7ww. Accessed August 1, 2012.
    1. Kruman II, Kumaravel TS, Lohani A, et al. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer’s disease. J Neurosci. 2002;22(5):1752–1762. - PMC - PubMed
    1. Ikeda T, Furukawa Y, Mashimoto S, et al. Vitamin B12 levels in serum and cerebrospinal fluid of people with Alzheimer’s disease. Acta Psychiatr Scand. 1990;82(4):327–329. - PubMed
    1. Karnaze DS, Carmel R. Low serum cobalamin levels in primary degenerative dementia. Do some patients harbor atypical cobalamin deficiency states? Arch Intern Med. 1987;147(3):429–431. - PubMed
    1. Bottiglieri T, Godfrey P, Flynn T, Carney MW, Toone BK, Reynolds EH. Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine. J Neurol Neurosurg Psychiatry. 1990;53(12):1096–1098. - PMC - PubMed

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