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Review
. 2014 Apr;14(4):426.
doi: 10.1007/s11882-014-0426-8.

Cross-reactivity of peanut allergens

Merima Bublin  1 , Heimo Breiteneder
Affiliations
Review

Cross-reactivity of peanut allergens

Merima Bublin et al. Curr Allergy Asthma Rep. 2014 Apr.

Abstract

Peanut seeds are currently widely used as source of human food ingredients in the United States of America and in European countries due to their high quality protein and oil content. This article describes the classification and molecular biology of peanut seed allergens with particular reference to their cross-reactivities. Currently, the IUIS allergen nomenclature subcommittee accepts 12 peanut allergens. Two allergens belong to the cupin and four to the prolamin superfamily, and six are distributed among profilins, Bet v 1-like proteins, oleosins, and defensins. Clinical observations frequently report an association of peanut allergy with allergies to legumes, tree nuts, seeds, fruits and pollen. Molecular cross-reactivity has been described between members of the Bet v 1-like proteins, the non-specific lipid transfer proteins, and the profilins. This review also addresses the less well-studied cross-reactivity between cupin and prolamin allergens of peanuts and of other plant food sources and the recently discovered cross-reactivity between peanut allergens of unrelated protein families.

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Conflict of interest statement

Merima Bublin declares that she has no conflict of interest.

Heimo Breiteneder has received support from the Austrian Science Fund grants SFB 4608 and doctoral program W 1248-B13.

Figures

Fig. 1
Fig. 1
Allergenic cupins and prolamins from peanut
Fig. 2
Fig. 2
Peanut allergens from the Bet v 1, profilin, oleosin, and defensin families
See this image and copyright information in PMC

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