Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jan;5(1):123-6.

Prevalence and Prognosis of Cerebrovascular Accidents and its Subtypes Among Patients with Systemic Lupus Erythematosus in Isfahan, Iran: A Hospital Clinic-based Study

Mohammad Saadatnia  1 , Zahra Sayed-Bonakdar  2 , Ghasem Mohammad-Sharifi  1 , Amir Hossein Sarrami  1
Affiliations

Prevalence and Prognosis of Cerebrovascular Accidents and its Subtypes Among Patients with Systemic Lupus Erythematosus in Isfahan, Iran: A Hospital Clinic-based Study

Mohammad Saadatnia et al. Int J Prev Med. 2014 Jan.

Abstract

Background: The aim of the present study was to determine the prevalence and prognosis of cerebrovascular accident (CVA) and its subtypes among Iranian patients with systemic lupus erythematosus (SLE).

Methods: In a cross-sectional study, medical records of 575 SLE patients were reviewed. The patients developing CVA in their course of disease were extracted. In these patients, data about demographic features, lupus anti bodies, duration of the disease until CVA, CVA manifestation(s) and follow-up duration were gathered. In the next step, patients with any kinds of CVA were summoned to Neurology clinic to identify the grade of disability in each patient with CVA.

Results: We identified 38 patients with CVA of which 6 (15.8%) were men and 32 (84.2%) were women. The most common subtype of CVA was small vessels thrombosis (21.05%) among the study patients and hemi paresis was the most prevalent initial presentation (39.47%). In 11 (28.9%) patients, SLE was initiated with CVA and in 3 (7.9%) patients CVA had happened in the 1(st) year of SLE. Anti-phospholipid antibodies (APLA) were positive in 29 (76.3%) patients. Mean modified Rankin Scale in patient with positive and negative serology for APLA was 0.93 ± 1.11 and 0.22 ± 0.66 respectively (P = 0.006).

Conclusions: Our study shows that 6.6% of Iranian SLE patients have CVA during their course of the disease. Small vessels thrombosis is the most common CVA subtype and hemi paresis is the most prevalent initial presentation. Moreover, we showed that the prognosis of CVA in Iranian SLE patients is not unfavorable.

Keywords: Cerebrovascular accident; stroke; systemic lupus erythamatosus.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Brey RL. Neuropsychiatric lupus: Clinical and imaging aspects. Bull NYU Hosp Jt Dis. 2007;65:194–9. - PubMed
    1. Schur PH, Gladman DD. Overview of the clinical manifestations of systemic lupus erythematosus in adults. In: Basow DS, editor. Up To Date. Waltham, MA: Up to Date; 2009.
    1. Sayed Bonakdara Z, Mohtasham N, Karimifara M. Evaluation of damage index and its association with risk factors in patients with systemic lupus erythematosus. Journal of Research in Medical Science. 2011;16(special issue):427–32. - PMC - PubMed
    1. Futrell N, Millikan C. Frequency, etiology, and prevention of stroke in patients with systemic lupus erythematosus. Stroke. 1989;20:583–91. - PubMed
    1. Krishnan E. Stroke subtypes among young patients with systemic lupus erythematosus. Am J Med. 2005;118:1415. - PubMed