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Comment
. 2014 Jan 7;111(1):E5.
doi: 10.1073/pnas.1321606111.

Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice

Christian S Lobsiger, Don W Cleveland
Comment

Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice

Christian S Lobsiger et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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    1. Lobsiger CS, et al. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci USA. 2013;110(46):E4385–E4392. - PMC - PubMed
    1. Woodruff TM, Lee JD, Noakes PG. Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proc Natl Acad Sci USA. 2014;111:E3–E4. - PMC - PubMed
    1. Huber-Lang M, et al. Generation of C5a in the absence of C3: A new complement activation pathway. Nat Med. 2006;12(6):682–687. - PubMed
    1. Lee JD, et al. Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis. J Neuroinflammation. 2013;10(1):119. - PMC - PubMed

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