Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Feb 21:12:40.
doi: 10.1186/1477-7819-12-40.

Prediction of tumor recurrence after curative resection in gastric carcinoma based on bcl-2 expression

Jianghong Wu, Xiaowen Liu, Hong Cai, Yanong Wang  1
Affiliations

Prediction of tumor recurrence after curative resection in gastric carcinoma based on bcl-2 expression

Jianghong Wu et al. World J Surg Oncol. .

Abstract

Background: There are currently no reliable predictive factors for gastric cancer recurrence. The aim of this study was to evaluate the relationship between bcl-2 expression and risk of gastric cancer recurrence.

Methods: From January 1996 to December 2007, 449 gastric cancer patients who underwent curative resection were retrospectively studied. The expression levels of bcl-2 were examined by immunohistochemistry. Logistic regression was performed to identify independent risk factors for overall recurrence of gastric cancer.

Results: 151 patients (33.6%) experienced recurrences. The median time to recurrence was 17.0 months, 113 (74.8%) patients had recurrences within 2 years. Peritoneal recurrence was the most prevalent pattern, followed by hematogenous metastasis in which the liver was the most common site. Depth of invasion, lymph node metastases, and negative expression of bcl-2 were independent risk factors for overall recurrence. The overall survival time of recurrent patients was 22.7 months. The median survival time after recurrence was 6.7 months.

Conclusion: The depth of invasion, lymph node metastases and expression of bcl-2 are independent factors for predicting gastric cancer recurrence.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Positive expression of bcl-2 immunohistochemistry in gastric cancer tissue. A original magnification ×100, B original magnification ×400.
Figure 2
Figure 2
Frequency of recurrence after curative operation by year.
Figure 3
Figure 3
Pattern of recurrence of after curative gastrectomy.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Shibata A, Parsonnet J. In: Cancer epidemiology and prevention. 3. Schottenfeld D, Fraumeni JF, editor. New York: Oxford University Press; 2006. Stomach cancer; pp. 707–720.
    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108. doi: 10.3322/canjclin.55.2.74. - DOI - PubMed
    1. Moriguchi S, Maehara Y, Korenaga D, Sugimachi K, Nose Y. Risk factors which predict pattern of recurrence after curative surgery for patients with advanced gastric cancer. SurgOncol. 1992;1:341–346. - PubMed
    1. Bohner H, Zimmer T, Hopfenmuller W, Berger G, Buhr HJ. Detection and prognosis of recurrent gastric cancer-is routine follow-up after gastrectomy worthwhile? Hepatogastroenterology. 2000;47:1489–1494. - PubMed
    1. Kim JH, Kim HS, Seo WY, Nam CM, Kim KY, Jeung HC, Lai JF, Chung HC, Noh SH, Rha SY. External validation of nomogram for the prediction of recurrence after curative resection in early gastric cancer. Ann Oncol. 2012;23:361–367. doi: 10.1093/annonc/mdr118. - DOI - PubMed

MeSH terms

Substances