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Review
. 2014 Sep;47(6):351-60.
doi: 10.3109/08916934.2014.889119. Epub 2014 Feb 20.

Genetic background of juvenile idiopathic arthritis

Dimitry A Chistiakov  1 , Kirill V Savost'anov, Alexander A Baranov
Affiliations
Free article
Review

Genetic background of juvenile idiopathic arthritis

Dimitry A Chistiakov et al. Autoimmunity. 2014 Sep.
Free article

Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children. JIA is a group of disorders that share the clinical manifestation of chronic joint inflammation. The human leukocyte antigen region (HLA) seems to be a major susceptibility locus for JIA that is estimated to account for 17% of familial segregation of the disease. To date, around 20 non-HLA loci conferring susceptibility to JIA were found. At least a half of those are shared between JIA and rheumatoid arthritis (RA), an adult rheumatic disease, thereby suggesting for similarity of pathogenic mechanisms of both diseases. New findings also suggest for a likely role of epigenetic alterations in the pathogenesis of JIA that should be investigated in the future.

Keywords: Genetic association; juvenile idiopathic arthritis; polymorphism; rheumatoid arthritis; susceptibility.

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