. 2014 Jan-Feb;14(1):27-35.

doi: 10.1016/j.pan.2013.10.009. Epub 2013 Nov 13.

Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest

Melena D Bellin¹, Martin L Freeman², Andres Gelrud³, Adam Slivka⁴, Alfred Clavel⁵, Abhinav Humar⁶, Sarah J Schwarzenberg⁷, Mark E Lowe⁸, Michael R Rickels⁹, David C Whitcomb¹⁰, Jeffrey B Matthews¹¹; PancreasFest Recommendation Conference Participants; Stephen Amann, Dana K Andersen, Michelle A Anderson, John Baillie, Geoffrey Block, Randall Brand, Suresh Chari, Marie Cook, Gregory A Cote, Ty Dunn, Luca Frulloni, Julia B Greer, Michael A Hollingsworth, Kyung Mo Kim, Alexander Larson, Markus M Lerch, Tom Lin, Thiruvengadam Muniraj, R Paul Robertson, Seth Sclair, Shalinender Singh, Rachelle Stopczynski, Frederico G S Toledo, Charles Melbern Wilcox, John Windsor, Dhiraj Yadav

Collaborators, Affiliations

Collaborators

PancreasFest Recommendation Conference Participants:
Venkata Akshintala, Samer Alhabhan, Inna Belfer, K Louise Berry, Lisa Bocelli, Sharon Boggiano, Brian Boone, Shailendra Chauhan, Jennifer Chennat, Angela Criscimanna, Sung Cho, Anthony Colatrella, Emmanuel Coronel, Siddhartha Das, Brian Davis, Christopher DiMaio, Danielle Dwyer, Jeffrey Easler, John Eisses, Devrim Eren, Farzad Esni, Christopher Forsmark, Steven Friedman, Roberto Gamarra, Cheryl Gariepy, Lisa Glass, April Goddard, Vay Liang Go, Tanja Gonska, Nalani Guda, Celia Hartigan, Wang Hongjun, Sandra Hubatch, Sohail Husain, Jennifer Jacob, Karen Jerome-Zapadka, Kathleen Kerr, Soma Kumar, Louis Lambiase, Jessica LaRusch, Peter Lee, Kenneth Lee, John Lieb, Veronique Morinville, A James Moser, Daniel Mullady, Nagaraj Nagathihalli, Haq Nawaz, Rawad Mounzer, Thiruvengadam Muniraj, Stephen O'Keefe, Alnabhan Samer, Seak Hee Oh, Joseph Palermo, Georgios Papachristou, Walter Park, Anoop Prabhu, Edward Purich, Mordechai Rabinovitz, Andrew Rhim, Emily Rolfsmeyer, Cynthia Rudert, Bimaljit Sandhu, Jose Serrano, Wednesday Sevilla, Vijay P Singh, Sheila Solomon, Ashok Srinivasan, Aliye Uc, Chandra Umapathy, Wahid Wassef, Yu Wen, Hongjun Wang

Affiliations

¹ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. Electronic address: bell0130@umn.edu.
² Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
³ Department of Medicine, University of Chicago, Chicago, IL, USA.
⁴ Department of Medicine, University of Pittsburgh, PA, USA.
⁵ Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
⁶ Department of Surgery, University of Pittsburgh, PA, USA.
⁷ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
⁸ Department of Pediatrics, University of Pittsburgh, PA, USA; Children's Hospital of Pittsburgh, PA, USA.
⁹ Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁰ Department of Medicine, University of Pittsburgh, PA, USA. Electronic address: whitcomb@pitt.edu.
¹¹ Department of Surgery, University of Chicago, Chicago, IL, USA.

PMID: 24555976
PMCID: PMC4058640
DOI: 10.1016/j.pan.2013.10.009

Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest

Melena D Bellin et al. Pancreatology. 2014 Jan-Feb.

. 2014 Jan-Feb;14(1):27-35.

doi: 10.1016/j.pan.2013.10.009. Epub 2013 Nov 13.

Authors

Collaborators

PancreasFest Recommendation Conference Participants:
Venkata Akshintala, Samer Alhabhan, Inna Belfer, K Louise Berry, Lisa Bocelli, Sharon Boggiano, Brian Boone, Shailendra Chauhan, Jennifer Chennat, Angela Criscimanna, Sung Cho, Anthony Colatrella, Emmanuel Coronel, Siddhartha Das, Brian Davis, Christopher DiMaio, Danielle Dwyer, Jeffrey Easler, John Eisses, Devrim Eren, Farzad Esni, Christopher Forsmark, Steven Friedman, Roberto Gamarra, Cheryl Gariepy, Lisa Glass, April Goddard, Vay Liang Go, Tanja Gonska, Nalani Guda, Celia Hartigan, Wang Hongjun, Sandra Hubatch, Sohail Husain, Jennifer Jacob, Karen Jerome-Zapadka, Kathleen Kerr, Soma Kumar, Louis Lambiase, Jessica LaRusch, Peter Lee, Kenneth Lee, John Lieb, Veronique Morinville, A James Moser, Daniel Mullady, Nagaraj Nagathihalli, Haq Nawaz, Rawad Mounzer, Thiruvengadam Muniraj, Stephen O'Keefe, Alnabhan Samer, Seak Hee Oh, Joseph Palermo, Georgios Papachristou, Walter Park, Anoop Prabhu, Edward Purich, Mordechai Rabinovitz, Andrew Rhim, Emily Rolfsmeyer, Cynthia Rudert, Bimaljit Sandhu, Jose Serrano, Wednesday Sevilla, Vijay P Singh, Sheila Solomon, Ashok Srinivasan, Aliye Uc, Chandra Umapathy, Wahid Wassef, Yu Wen, Hongjun Wang

Affiliations

¹ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. Electronic address: bell0130@umn.edu.
² Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
³ Department of Medicine, University of Chicago, Chicago, IL, USA.
⁴ Department of Medicine, University of Pittsburgh, PA, USA.
⁵ Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
⁶ Department of Surgery, University of Pittsburgh, PA, USA.
⁷ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
⁸ Department of Pediatrics, University of Pittsburgh, PA, USA; Children's Hospital of Pittsburgh, PA, USA.
⁹ Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁰ Department of Medicine, University of Pittsburgh, PA, USA. Electronic address: whitcomb@pitt.edu.
¹¹ Department of Surgery, University of Chicago, Chicago, IL, USA.

PMID: 24555976
PMCID: PMC4058640
DOI: 10.1016/j.pan.2013.10.009

Abstract

Description: Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical procedure used to treat severe complications of chronic pancreatitis or very high risk of pancreatic cancer while reducing the risk of severe diabetes mellitus. However, clear guidance on indications, contraindications, evaluation, timing, and follow-up are lacking.

Methods: A working group reviewed the medical, psychological, and surgical options and supporting literature related to TPIAT for a consensus meeting during PancreasFest.

Results: Five major areas requiring clinical evaluation and management were addressed: These included: 1) indications for TPIAT; 2) contraindications for TPIAT; 3) optimal timing of the procedure; 4) need for a multi-disciplinary team and the roles of the members; 5) life-long management issues following TPIAP including diabetes monitoring and nutrition evaluation.

Conclusions: TPIAT is an effective method of managing the disabling complications of chronic pancreatitis and risk of pancreatic cancer in very high risk patients. Careful evaluation and long-term management of candidate patients by qualified multidisciplinary teams is required. Multiple recommendations for further research were also identified.

Keywords: Diabetes mellitus; Hereditary pancreatitis; Pancreatic adenocarcinoma; Pancreatic cancer; Pancreatic surgery.

PubMed Disclaimer

Comment in

Pancreatitis: Is TPIAT the answer for treatment of chronic pancreatitis?
Beilman G. Beilman G. Nat Rev Gastroenterol Hepatol. 2014 Mar;11(3):144-5. doi: 10.1038/nrgastro.2014.11. Epub 2014 Feb 4. Nat Rev Gastroenterol Hepatol. 2014. PMID: 24492275 No abstract available.

References

1. Rickels MR, Bellin M, Toledo FGS, Robertson RP, Andersen DK, Chari ST, et al. Detection, Evaluation and Treatment of Diabetes Mellitus in Chronic Pancreatitis: Recommendations from PancreasFest 2012. Pancreatology. 2013;13(4):336–42. - PMC - PubMed
1. Cui Y, Andersen DK. Pancreatogenic diabetes: special considerations for management. Pancreatology : official journal of the International Association of Pancreatology. 2011;11(3):279–94. Epub 2011/07/16.eng. - PubMed
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Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest

Collaborators

Affiliations

Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest

Authors

Collaborators

Affiliations

Abstract

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical