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. 2014 Apr;57(5):216-9.
doi: 10.1016/j.ejmg.2014.02.004. Epub 2014 Feb 18.

Neuropsychological impairments in elderly Neurofibromatosis type 1 patients

Danielle de Souza Costa  1 , Jonas Jardim de Paula  2 , Nilton Alves de Rezende  3 , Luiz Oswaldo Carneiro Rodrigues  4 , Leandro Fernandes Malloy-Diniz  5 , Marco Aurélio Romano-Silva  6 , Débora Marques de Miranda  7
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Neuropsychological impairments in elderly Neurofibromatosis type 1 patients

Danielle de Souza Costa et al. Eur J Med Genet. 2014 Apr.

Abstract

Cognitive performance is compromised in Neurofibromatosis type 1 (NF1) patients, but neuropsychological data including elderly NF1 are extremely sparse. We compared the cognitive performance of a small elderly NF1 group (n = 5) with an age-matched healthy control group (n = 49). NF1 group performed worse than control group on a global cognitive impairment task, verbal working memory, and visuospatial functioning. The results suggest that cognitive impairment is an important feature of NF1 across lifespan, including elderly individuals. Future studies approaching the NF1 cognitive profile might benefit from looking at the mechanisms linked to the age-related aspects of cognitive decline.

Keywords: Aging; Cognition; Elderly; Neurofibromatosis type 1; Neuropsychology.

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