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Review
. 2014 Mar 1;74(5):1287-93.
doi: 10.1158/0008-5472.CAN-13-2825. Epub 2014 Feb 20.

Monocyte subpopulations in angiogenesis

Heather J Dalton  1 , Guillermo N Armaiz-Pena, Vianey Gonzalez-Villasana, Gabriel Lopez-Berestein, Menashe Bar-Eli, Anil K Sood
Affiliations
Review

Monocyte subpopulations in angiogenesis

Heather J Dalton et al. Cancer Res. .

Abstract

Growing understanding of the role of the tumor microenvironment in angiogenesis has brought monocyte-derived cells into focus. Monocyte subpopulations are an increasingly attractive therapeutic target in many pathologic states, including cancer. Before monocyte-directed therapies can be fully harnessed for clinical use, understanding of monocyte-driven angiogenesis in tissue development and homeostasis, as well as malignancy, is required. Here, we provide an overview of the mechanisms by which monocytic subpopulations contribute to angiogenesis in tissue and tumor development, highlight gaps in our existing knowledge, and discuss opportunities to exploit these cells for clinical benefit.

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Figures

Figure 1
Figure 1
Phenotypic diversity of monocyte subpopulations. Cells are shown with characteristic surface receptors, along with chemokines, cytokines and other characteristic factors when appropriate. Known pro-angiogenic factors are highlighted in red.
See this image and copyright information in PMC

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