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. 2014 Jun 1;28(9):1357-63.
doi: 10.1097/QAD.0000000000000245.

Acute HIV-1 infection is as common as malaria in young febrile adults seeking care in coastal Kenya

Eduard J Sanders  1 , Peter Mugo, Henrieke A B Prins, Elizabeth Wahome, Alexander N Thiong'o, Grace Mwashigadi, Elisabeth M van der Elst, Anisa Omar, Adrian D Smith, Susan M Graham
Affiliations
Free PMC article

Acute HIV-1 infection is as common as malaria in young febrile adults seeking care in coastal Kenya

Eduard J Sanders et al. AIDS. .
Free PMC article

Abstract

Background: Febrile adults are usually not tested for acute HIV-1 infection (AHI) in Africa. We assessed a strategy to diagnose AHI among young adult patients seeking care.

Methods: Young adults (<30 years) who met predefined AHI criteria at care seeking, including fever, sexually transmitted disease symptoms, diarrhoea, body pains or multiple partners were referred from five pharmacies and screened at five health facilities. Prevalent HIV-1 was diagnosed by nationally recommended serial rapid HIV-1 testing. Willing HIV-1-negative patients were evaluated for AHI, defined as a positive p24 antigen test, and subsequent seroconversion or RNA detection. Febrile patients evaluated for AHI were also screened for malaria using a rapid test, with PCR confirmation of positives.

Results: In 3602 adults seeking care, overall HIV-1 prevalence was 3.9%: 7.6% (68/897) among patients meeting AHI criteria vs. 2.6% (71/2705) among those who did not (P < 0.001). AHI was diagnosed in five of 506 HIV-1-negative or discordant patients who met AHI risk criteria and were completely evaluated [prevalence 1.0%, 95% confidence interval (CI) 0.3-2.3%]. Of these five AHI cases, four were diagnosed among the 241 patients with fever (prevalence 1.7%, 95% CI 0.5-4.2%), vs. one among 265 non-febrile patients (prevalence 0.4%, 95% CI 0.0-2.0%, P = 0.1). Malaria was confirmed by PCR in four (1.7%) of the 241 febrile patients.

Conclusion: AHI was as common as confirmed malaria in young febrile adults seeking care. An AHI detection strategy targeting young febrile adults seeking care at pharmacies and health facilities is feasible and should be considered as an HIV-prevention strategy in high-transmission settings.

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Figures

Fig. 1
Fig. 1
Patient flow, clinical screening, HIV-1 testing, and acute HIV-1 infection evaluation.
See this image and copyright information in PMC

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