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Comment
. 2014 Mar 11;111(10):3657-8.
doi: 10.1073/pnas.1401037111. Epub 2014 Feb 20.

Ancient insights into uric acid metabolism in primates

Belinda S W Chang  1
Affiliations
Comment

Ancient insights into uric acid metabolism in primates

Belinda S W Chang. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic representation of a mammalian phylogeny, showing the experimentally recreated uricase ancestors for which enzymatic activity was measured by Kratzer et al. (13). (Inset) Ancestral mammalian uricase crystal structure (13). Approximate geologic timescale is indicated below.
See this image and copyright information in PMC

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References

    1. Zhu YY, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011;63(10):3136–3141. - PubMed
    1. Go AS, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart disease and stroke statistics—2013 update: A report from the American Heart Association. Circulation. 2013;127(1):e6–e245. - PMC - PubMed
    1. Ayub Q, et al. Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes. Am J Hum Genet. 2014;94(2):176–185. - PMC - PubMed
    1. Pauling L, Zuckerkandl E. Chemical paleogenetics: Molecular ‘restoration studies’ of extinct forms of life. Acta Chem Scand. 1963;17:9–16.
    1. Cannarozzi GM, Schneider A, eds (2012) Codon Evolution: Mechanisms and Models (Oxford Univ Press, Oxford)

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