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Review
. 2014 Jun;45(2):126-32.
doi: 10.1007/s12029-014-9583-1.

H. pylori infection, inflammation and gastric cancer

Qurteeba Qadri  1 , Roohi Rasool, G M Gulzar, Sameer Naqash, Zafar A Shah
Affiliations
Review

H. pylori infection, inflammation and gastric cancer

Qurteeba Qadri et al. J Gastrointest Cancer. 2014 Jun.

Abstract

Introduction: A strong association between chronic infection, inflammation, and cancer has been suggested.

Discussion: Helicobacter pylori, a microaerophilic gram negative bacterium, infects about half the world's population. It has been defined as a definitive carcinogen in the pathogenesis of gastric cancer. H. pylori evades the host immune responses and persists in the stomach leading to gastritis gastric atrophy and sometimes gastric cancer.

Conclusion: Chronic H. pylori infection causes gastric cancer via two mechanisms: the presence of virulence factors and the induction of chronic inflammation which ultimately leads to neoplastic transformation.

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