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Comment
. 2014 Feb 20;123(8):1123-4.
doi: 10.1182/blood-2013-12-543397.

Inhibit the calpain to climb the mountain

Rafal Pawlinski  1
Affiliations
Comment

Inhibit the calpain to climb the mountain

Rafal Pawlinski. Blood. .

Abstract

In this issue of Blood, Tyagi et al shed some light on the mechanism of thrombosis induced by a high altitude, hypoxic environment. Using proteomic analysis of platelets and in vivo models of thrombosis, the authors elegantly demonstrated that enhanced calpain activity, regulated by CAPNS1, significantly contributes to platelet reactivity and thrombosis under hypoxic conditions. The observations from animal models were further supported by human data showing increased calpain activity and elevation in markers of platelet activation in the plasma of patients who developed deep vein thrombosis at high altitude.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Comment on

References

    1. Tyagi T, Ahmad S, Gupta N, et al. Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype. Blood. 2014;123(8):1250–1260. - PubMed
    1. Croce K, Flaumenhaft R, Rivers M, Furie B, Furie BC, Herman IM, Potter DA. Inhibition of calpain blocks platelet secretion, aggregation, and spreading. J Biol Chem. 1999;274(51):36321–36327. - PMC - PubMed
    1. Azam M, Andrabi SS, Sahr KE, Kamath L, Kuliopulos A, Chishti AH. Disruption of the mouse mu-calpain gene reveals an essential role in platelet function. Mol Cell Biol. 2001;21(6):2213–2220. - PMC - PubMed
    1. Randriamboavonjy V, Isaak J, Elgheznawy A, et al. Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. Blood. 2012;120(2):415–423. - PubMed
    1. Pasquet JM, Dachary-Prigent J, Nurden AT. Calcium influx is a determining factor of calpain activation and microparticle formation in platelets. Eur J Biochem. 1996;239(3):647–654. - PubMed