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. 2013 Aug 26;3(2):124.
doi: 10.4172/2161-0460.1000124.

Poor Sleep as a Precursor to Cognitive Decline in Down Syndrome : A Hypothesis

Fabian Fernandez  1 , Jamie O Edgin  2
Affiliations

Poor Sleep as a Precursor to Cognitive Decline in Down Syndrome : A Hypothesis

Fabian Fernandez et al. J Alzheimers Dis Parkinsonism. .

Abstract

We propose that sleep disruption is a lever arm that influences how cognition emerges in development and then declines in response to Alzheimer disease in people with Down syndrome. Addressing sleep disruptions might be an overlooked way to improve cognitive outcomes in this population. This article is a contribution to a Special Issue on Down Syndrome curated by the editors of the Journal of Alzheimer's Disease & Parkinsonism.

Keywords: Alzheimer’s disease; Circadian arrhythmia; Down syndrome; Sleep disruption.

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