Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Apr;13(4):305-9.
doi: 10.1007/BF00972478.

Acute reduction of brain substance P induced by nicotine

N E Naftchi  1 , H Maker, E Lapin, J Sleis, A Lajtha, S Leeman
Affiliations

Acute reduction of brain substance P induced by nicotine

N E Naftchi et al. Neurochem Res. 1988 Apr.

Abstract

Ten minutes after a single injection of 0.8 mg/kg nicotine SC (free base) the level of substance P-like immunoreactivity (SPLI) was reduced by 61-73% in rat caudate-putamen, nucleus accumbens, and olfactory tubercle, with smaller and not significant reductions in the frontal cortex, substantia nigra, and ventral tegmental area. The nicotinic receptor antagonist mecamylamine (1.0 mg/kg IP) prevented the reductions in SPLI. The rapidity and the degree of the changes in SPLI after nicotine exceed those previously reported for other agents and implicate substance P neurotransmission as a major component of nicotinic action.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Brain Res. 1976 Nov 5;116(2):299-305 - PubMed
    1. Brain Res. 1976 May 14;107(3):623-7 - PubMed
    1. Brain Res. 1987 Mar 31;407(2):351-63 - PubMed
    1. Brain Res. 1977 May 13;126(3):576-9 - PubMed
    1. Acta Physiol Scand. 1981 Jul;112(3):345-7 - PubMed

Publication types