Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jul;85(14):5176-80.
doi: 10.1073/pnas.85.14.5176.

Adhesion domain of human T11 (CD2) is encoded by a single exon

N E Richardson  1 , H C Chang, N R Brown, R E Hussey, P H Sayre, E L Reinherz
Affiliations

Adhesion domain of human T11 (CD2) is encoded by a single exon

N E Richardson et al. Proc Natl Acad Sci U S A. 1988 Jul.

Abstract

The 50-kDa T11 (CD2) T-lymphocyte surface glycoprotein facilitates physical adhesion between T-lineage cells and their cognate cellular counterparts (cytotoxic T-lymphocytes-target cells, helper T lymphocytes-antigen-presenting cells, or thymocytes-thymic epithelium) as well as signaling through the antigen-specific T3-Ti receptor complex. To examine the relationship between the structure and function of the T11 molecule, we have utilized a baculoviral expression system to produce milligram quantities of the hydrophilic extracellular T11 segment. Enzyme cleavage, microsequencing, and HPLC analyses of the expressed protein in conjunction with genomic cloning information show that the domain involved in cellular adhesion is encoded by a single 321-base-pair exon.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Exp Med. 1982 May 1;155(5):1317-33 - PubMed
    1. Eur J Immunol. 1982 Jan;12(1):81-6 - PubMed
    1. J Immunol. 1985 Feb;134(2):1084-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8404-8 - PubMed
    1. Nature. 1986 Sep 18-24;323(6085):262-4 - PubMed

MeSH terms

LinkOut - more resources