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Comment
. 2014 Feb 19;81(4):720-2.
doi: 10.1016/j.neuron.2014.02.002.

A Drosophila circuit feels the (sleep) pressure

Güliz Gürel Ozcan  1 , Jason Rihel  2
Affiliations
Comment

A Drosophila circuit feels the (sleep) pressure

Güliz Gürel Ozcan et al. Neuron. .

Abstract

How sleep is homeostatically regulated remains a mystery. In this issue of Neuron, Donlea et al. (2014) provide evidence in Drosophila that a set of sleep-inducing neurons require Crossveinless-c, a specific Rho-GTPase-activating protein (Rho-Gap), to alter their membrane excitability in response to sleep deprivation.

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Figures

Figure 1
Figure 1
A Drosophila Sleep Pressure Point in the Fan-Shaped Body? (A) During low sleep pressure states, sleep-promoting FB neurons remain at their baseline excitability. (B) After sleep deprivation, sleep pressure signals are transmuted into increased electrical excitability of FB neurons in a process that requires functional Cv-c. The FB neurons are shown in context with wake-promoting dopamine neurons, which inhibit FB neurons and reduce sleep.
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