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Review
. 2014 Apr;63(4):441-51.
doi: 10.1016/j.metabol.2014.01.006. Epub 2014 Jan 17.

The many roles of PGC-1α in muscle--recent developments

Mun Chun Chan  1 , Zolt Arany  2
Affiliations
Review

The many roles of PGC-1α in muscle--recent developments

Mun Chun Chan et al. Metabolism. 2014 Apr.

Abstract

Skeletal muscle is the largest organ in the body and contributes to innumerable aspects of organismal biology. Muscle dysfunction engenders numerous diseases, including diabetes, cachexia, and sarcopenia. At the same time, skeletal muscle is also the main engine of exercise, one of the most efficacious interventions for prevention and treatment of a wide variety of diseases. The transcriptional coactivator PGC-1α has emerged as a key driver of metabolic programming in skeletal muscle, both in health and in disease. We review here the many aspects of PGC-1α function in skeletal muscle, with a focus on recent developments.

Keywords: Metabolism; Muscle; PGC-1alpha.

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Conflict of interest statement

Conflict-of-interest/financial disclosure statement: none

Figures

Figure 1
Figure 1. Regulation and roles of PGC-1α in skeletal muscle
Exercise and calorie restriction induce PGC-1α expression and activation. Induction of PGC-1α affects multiple pathways and processes in the myocyte, as well as systemic physiological effects.
Figure 2
Figure 2. The many isoforms of PGC-1α
A. Schema of PGC-1α alternative and proximal promoter (top) and of the different PGC-1α isoforms (bottom), along with the names for isoforms used in different publications. Numbers above the isoform are amino acid sequence compared to PGC-1α1/PGC-1α-a isoform. Numbers below the isoforms are amino acid sequence not found on PGC-1α1/PGC-1α-a. References are given in parentheses.
See this image and copyright information in PMC

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