doi: 10.1007/BF02142536.
Effect of stobadine on stimulated isolated mast cells
Affiliations
- PMID: 2455985
- DOI: 10.1007/BF02142536
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Effect of stobadine on stimulated isolated mast cells
Agents Actions.
1988 Apr.
Abstract
Stobadine, an antiarrhythmic drug with antihistaminic properties, did not liberate histamine from mast cells in vitro. Compound 48/80-stimulated histamine liberation and degranulation was decreased in the presence of stobadine in a dose-dependent way. The spontaneous as well as stimulated calcium displacement in mast cells was significantly decreased by stobadine. Stobadine most probably possesses a membrane-stabilizing effect on isolated rat mast cells.
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