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. 1988 Apr;23(3-4):188-90.
doi: 10.1007/BF02142536.

Effect of stobadine on stimulated isolated mast cells

K Drábiková  1 , J Pecivová, R Nosál
Affiliations

Effect of stobadine on stimulated isolated mast cells

K Drábiková et al. Agents Actions. 1988 Apr.

Abstract

Stobadine, an antiarrhythmic drug with antihistaminic properties, did not liberate histamine from mast cells in vitro. Compound 48/80-stimulated histamine liberation and degranulation was decreased in the presence of stobadine in a dose-dependent way. The spontaneous as well as stimulated calcium displacement in mast cells was significantly decreased by stobadine. Stobadine most probably possesses a membrane-stabilizing effect on isolated rat mast cells.

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