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Comment
. 2014 Feb 20;40(2):167-9.
doi: 10.1016/j.immuni.2014.01.009.

Constitutive antiviral immunity at the expense of autoimmunity

John A Todd  1
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Comment

Constitutive antiviral immunity at the expense of autoimmunity

John A Todd. Immunity. .
Free article

Abstract

In this issue of Immunity, Funabiki et al. (2014) have identified in mice a mutation of the IFIH1 gene, encoding the viral receptor MDA5 that causes constitutive IFN production and fatal autoimmune disease. The authors show that the autoimmune disease-associated variant of human MDA5 is permanently switched on.

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