Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Feb 27;156(5):1072-83.
doi: 10.1016/j.cell.2014.01.044. Epub 2014 Feb 20.

Neurogenesis in the striatum of the adult human brain

Aurélie Ernst  1 , Kanar Alkass  2 , Samuel Bernard  3 , Mehran Salehpour  4 , Shira Perl  5 , John Tisdale  5 , Göran Possnert  4 , Henrik Druid  6 , Jonas Frisén  7
Affiliations
Free article

Neurogenesis in the striatum of the adult human brain

Aurélie Ernst et al. Cell. .
Free article

Abstract

In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.

PubMed Disclaimer

Comment in

Publication types